I. Emrah Nikerel

Ph.D Student, Research & Teaching Assistant

 Last Updated: 29-11-2008

B.Sc in ChE, Bogazici Un., 2001

M.Sc in ChE, Bogazici Un., 2003

 
i.e.nikerel-tudelft.nl
(for professional e-mails)

emrah-nikerel.net
(for anything else ;) )

Delft University of Technology
Department of Biotechnology
Julianalaan 67
2628 BC, Delft
The Netherlands

 
+31 15 278 23 52

For my personal, fun home page, click here.

RESEARCH ACTIVITIES

Currently, I am a PhD candidate junior researcher at Technical University of Delft (TU Delft). I am working on Software development for integrative modeling of transcriptome, proteome and metabolome. More information can be found at the departments page, precisely here. In a general sense, I am interested in modeling of metabolic systems by (approximative) kinetic models.

SCIENTIFIC OUTPUT

  • Published papers
  • Oral presentations
  • Poster presentations
  • Supervised MSc. Theses
  • PAPERS

    Nikerel I.E., van Winden W.A, Verheijen P.J.T, Heijnen J.J, "Model reduction and a priori kinetic parameter identifiability analysis using metabolome time series for metabolic reaction networks with linlog kinetics Metabolic Engineering', Metabolic Engineering, January 2009, Vol 11(1), pp 20-30, Available Online

    Gunay M.E., Nikerel I.E., Oner E.T., Kirdar B., Yildirim R., "Simultaneous modeling of enzyme production and biomass growth in recombinant Escherichia coli using artificial neural networks", Biochemical Engineering Journal, December 2008, Vol. 42(3), pp 329-335, Available online

    Nikerel IE, Ateş O, Oner ET., "Effect of bioprocess conditions on growth and alkaline protease production by halotolerant Bacillus licheniformis BA17", Applied Biochemistry and Microbiology (Prikladnaya Biokhimiya i Mikrobiologiya),September 2008, Vol. 44(5), pp539-44. Available online

    Nikerel I.E., van Winden W.A, van Gulik W.M, Heijnen J.J, "A method for estimation of elasticities in metabolic networks using steady state and dynamic metabolomics data and linlog kinetic", BMC Bioinformatics, 2006, 7:540 Available online,Open Access

    Nikerel I.E., Oner E.T., Kirdar B., Yildirim R., "Optimization of medium composition for biomass production of recombinant Escherichia coli cells using response surface methodology, Biochemical Engineering Journal, November 2006, Vol(32), pp 1-6, Available online

    Nikerel I.E., van Winden W.A, van Gulik W.M, Heijnen J.J., Linear-logarithmic kinetics: a framework for modeling kinetics of metabolic reaction networks" Proceedings of the 5th Vienna Symposium on Mathematical Modeling, February 2006, Volume II, ARGESIM Report No: 30, Vienna, Austria (Local Copy)

    Nikerel I.E., Toksoy E.T., Kirdar B., Yildirim R., "Optimizing medium composition for TaqI endonuclease production by recombinant Escherichia coli cells using response surface methodology", Process Biochemistry, April 2005, Vol40(5),pp 1633-1639 available online

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    ORAL PRESENTATIONS

    "Dynamic Modeling of Metabolic Reaction Networs: Challenges, Pitfalls, Practical Solutions", Netherlands Process Symposium-8, Session: Kinectics & Conversions October 29th, 2008 

    "Kinetic parameter identifiability analysis and model reduction" IVth Kluyver Centre Symposium, Noordwijkerhout, the Netherlands, (30 Jan - 01 February 2007)

    "Linear-logarithmic kinetics: a framework for modeling kinetics of metabolic reaction networks, 5th Vienna Symposium on Mathematical Modeling (Session: Modeling and simulation in Systems Biology), Vienna, Austria (8-10 February 2006)

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    POSTER PRESENTATIONS

    Nikerel I.E., Verheijen P.J.T, Heijnen J.J.,"Development of large scale kinetic models for metabolic networks: challenges, pitfalls, practical solutions", Metabolic Engineering VII, Puerto Vallarta, Mexico (14-19 September 2008)

    Nikerel I.E., van Winden W.A, Heijnen J.J, “Model reduction via time scale analysis for metabolic reaction networks using linlog kinetics”, Metabolic Engineering VI, Noordwijkerhout, Netherlands, (1-5 October 2006).

    Nikerel I.E., van Winden W.A, van Gulik W.M, Heijnen J.J, “A method for estimation of in vivo elasticities from dynamic and steady-state data, using linlog kinetics.”, 2nd Kluyver Centre Symposium, Noordwijkerhout, Netherlands (1-3 February 2005).

    Nikerel I.E., van Winden W.A, van Gulik W.M, Heijnen J.J, “Dynamic Simulation of the Glycolysis in Saccharomyces cerevisae Using linlog Kinetics.”  11th Workshop of the BioThermoKinetics Study Group, Developing concepts for systems biology (BTK-11), Oxford, ENGLAND (3-6 September 2004)

    Nikerel I.E., van Winden W.A, van Gulik W.M, Heijnen J.J, “A method for the estimation of elasticities using linlog kinetics.”  5th International Conference on Systems Biology, Heidelberg, GERMANY (9-13 October 2004)

    İ.E.,Toksoy Öner, E.,Yıldırım, R, B. Kirdar, ‘Medium Optimization for TaqI Endonuclease Production by Recombinant E.coli cells' , 11th European Congress on Biotechnology (ECB-11) , Basel- SWITZERLAND, (August 24-29 2003)

    Nikerel, İ.E.,Toksoy Öner, E., Yıldırım, R, B. Kirdar, " Statistical Optimization of Medium for the Production of Taq I Endonuclease from Recombinant Escherichia coli Cells Using Response Surface Methodology", 3rd Chemical Engineering Conference for Collaborative Research in Eastern Mediterranean (EMCC-3), Thessaloniki, GREECE (13-15 May 2003)

    Nikerel I.E, Toksoy E.T., Yıldırım R., Kırdar B., 'Rekombinant Escherichia coli hucrelerinde TaqI endonükleaz üretiminin Yanıt Yüzeyi Yöntemi ile istatistiksel optimizasyonu' , 5. Ulusal Kimya Mühendisligi Kongresi (UKMK-5), Ankara- TURKEY (September 2-5, 2002) - poster presentation

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    SUPERVISED MASTER THESES

  • Stefan Jol, 2007, Modeling anaerobic glycolysis in S. cerevisiae: a model-based experimental design approach.
  • Raymond Blankestijn, 2007, In vivo whole cell mathematical model for metabolic reaction network for model organism Penicillium chrysogenum
  • Niek van de Pas, 2006, In silico analysis of signal transduction network, 'The TOR case'

    COURSES TAKEN WITHIN THE SCOPE OF BIOCHEMICAL ENGINEERING
    ChE 427 (Biochemical Engineering I) ChE 680 (Advanced Bioreaction Engineering)
    ChE 480 (Bioprocess Design) ChE 681 (Genome-scale Metabolic Engineering)
    ChE 529 (Metabolic Engineering) ChE 682(Biotechnology for Health)
    ChE 594 (Molecular Biotechnology) BM 597 (Biosensors)
       
    LST LM 3431: Metabolic Engineering II, Analysis of Metabolic Networks
    ESF course:      Modelling Metabolic and Signal Transduction Networks